VivoTag® fluorochromes are designed specifically to enable customized development of novel superbright fluorescent imaging agents. Provide superbright, stable fluorescence for longer times. Minimal cytotoxicity, narrow size distribution, highly functionalized. Customizable targeting with chosen fluorochrome and amine-reactive molecules, such as NHS esters, anhydrides or EDC activated carboxylates.
AminoSpark® nanoparticles are a family of highly fluorescent near infrared nanoparticles specifically designed for in vivo imaging. AminoSPARKS comprise an iron oxide core that is coated to specifically produce a functionalized biocompatible product. AminoSPARK® 680 contains an amine-functionalized surface that serves as an optical platform, suitablefor further chemistry and conjugation to a variety of amine reactive molecules. AminoSPARK nanoparticles can be derivatized with amine reactive molecules, such as NHS esters, anhydrides or EDC activated carboxylates, using standard amine coupling conditions.
A lypophilic NIR dye like the XenoLight DiR is ideal for staining the cytoplasmic membrane, resulting in specific and stable cell staining with negligible dye transfer between cells.
XenoLight CF™ labeling kits provide a flexible solution for labeling proteins, peptides or antibodies. Available in a 680 nm, 750 nm or 770nm dye formulation, XenoLight CF kits are ideal for in vivo optical imaging. The low immunogenicity coupled with high solubility and >95% reactivity results in conjugates that are highly specific, bright and with improved half life.
VivoTrack 680 fluorescent agent is a water soluble NIR cell labeling agent that can label a variety of cell types for applications in inflammation, immunology, and stem cells. Explorer kit contains 1 vial containing 0.2mg of VivoTrack 680 that can label up to 2 x 10（8） cells. Track stem cells, T cells, macrophages and many other cell types longitudinally in vivo Water soluble - no need for harsh organics such as DMSO or ethanol, chemicals known to affect cell function. Homogeneous cell staining with no impact on cell viability Optimized for in vivo use with PerkinElmer’s in vivo imaging instruments
XenoLight DiR (DiIC18(7) or 1,1’-dioctadecyltetramethyl indotricarbocyanine Iodide). XenoLight DiR is a lipophilic, near infra-red (NIR) fluorescent cyanine dye ideal for staining cytoplasmic membrane. The two long 18-carbon chains insert into the cell membrane, resulting in specific and stable cell staining with negligible dye transfer between cells. Absorption/Emission: 748/780 nm Ideal IVIS filter set: 710 ex/760 em. For non-invasive imaging of T-cell or stem cell homing in vivo . The near infrared property of this dye makes it ideal for in vivo imaging because of significantly reduced autofluorescence from the animal at higher wavelengths.
1mg. VivoTag 680 XL Fluorochrome is an amine-reactive near infrared (NIR) fluorochrome for coupling via a NHS ester linkage to peptides, small molecules, proteins, antibodies, nanoparticales or other macromolecules. This fluorochrome exhibits lower quenching than VivoTag-S family of dyes. Hydrolytically stable and low self quenching for higher loading applications.
1 mg. VivoTag-S fluorochrome is an amine-reactive near-infra-red fluorochrome for coupling via an NHS ester linkage to peptides, small molecules, proteins, antibodies or macromolecules. The NHS ester moiety reacts with amino groups at pH 7-9 to form stable amide bonds. Lysines within proteins, including antibodies, are available as targets for this chemical conjugation. Absorbance 673 ± 5 nm Emission 691 ± 5 nm Optimized for single molecule loading. Amine-reactive for labeling via an NHS ester linkage.
1 mg. VivoTag-S 750 is an amine-reactive near-infrared (NIR) fluorochrome for coupling via an N-Hydroxysuccinimide (NHS)-ester linkage to peptides, small molecules, proteins, antibodies or macromolecules. Excitation 750 ± 5 nm Emission 775 ± 5 nm. N-Hydroxysuccinimide (NHS)-ester labeling reagents, such as VivoTag-S 750 fluorochrome reagent, is commonly used for labeling proteins. The NHS ester moiety reacts with amino groups at pH 7-9 to form stable amide bonds. Lysines within proteins, including antibodies, are available as targets for this chemical conjugation.
1mg. VivoTag-S® 750-MAL is a thiol (-SH, sulfhydryl) reactive maleimide-containing NIR fluorochrome for molecular labeling applications. Thiol-reactive for coupling via maleimide chemistry to label free cysteines or thiol groups. VivoTag-S 750-MAL enables optimized and integrated imaging applications in both in vivo and in vitro applications. VivoTag-S 750-MAL’s superior brightness makes it particularly well suited for the labeling of thiol and cysteine containing molecules for a wide range of imaging applications. It is optimized for use with fluorescence tomography FMT™ imaging systems with expanded wavelength capabilities to enable quantitative imaging of up to four channels and four different biomarkers of interest in vivo.
1mg. VivoTag 645 is an amine reactive red fluorochrome (NHS ester) for molecular labeling applications. near infrared (NIR) Fluorochrome for coupling via a NHS ester linkage to peptides, small molecules, proteins, antibodies or macromolecules. VivoTag 645 Fluorochrome enables optimized and integrated imaging applications in both in vivo and in vitro applications. VivoTag 645's superior brightness makes it particularly well suited for the labeling and imaging of proteins, antibodies, and small molecules in a wide range of research areas.
1mg. VivoTag® 800 is an amine-reactive near infrared (NIR) fluorochrome for coupling via a NHS ester linkage to peptides, small molecules, proteins, antibodies, nanoparticales or other macromolecules. This fluorochrome exhibits lower quenching than VivoTag-S family of dyes. Excitation 785 nm; Emission 810 nm; Absorbance 787 ± 5 nm
1mg. A thiol (-SH, sulfhydryl) reactive maleimide-containing red fluorochrome for molecular labeling applications. The NHS ester moiety on VivoTag 645-MAL reacts with amino groups to form amide bonds. Lysines within proteins, including antibodies, are available as targets for this chemical conjugation. VivoTag 645-MAL enables optimized and integrated imaging applications in both in vivo and in vitro applications. VivoTag 645-MAL’s superior brightness makes it particularly well suited for the labeling of thiol and cysteine containing molecules for a wide range ofimaging applications. The 645 nm fluorescence wavelength is ideal for biological imaging applications on in vitro and in vivo fluorescence systems, including advanced microscopes, high content imaging and flow cytometry systems. It is also optimized for use with fluorescence tomography FMT® imaging systems with expanded wavelength capabilities to enable quantitative imaging of up to four channels and four different biomarkers of interest in vivo
1mg. VivoTag® 680XL-MAL is a thiol (-SH, sulfhydryl) reactive maleimide-containing near infrared (NIR) fluorochrome for molecular labeling applications. Optimized and integrated imaging for both in vivo and in vitro applications. VivoTag 680XL-MAL’s superior brightness makes it particularly well suited for the labeling of thiol and cysteine containing molecules for a wide range of imaging applications. The 680 nm fluorescence wavelength is ideal for biological imaging applications on in vitro and in vivo fluorescence systems, including advanced microscopes, high content imaging and flow cytometry systems. VivoTag 680 XL-MAL fluorochrome is optimized for use with fluorescence tomography FMT® imaging systems with expanded wavelength capabilities to enable quantitative imaging of up to four channels and four different biomarkers of interest in vivo.
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