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Activatable fluorescent imaging agents enable in vivo imaging of biological processes. Non-fluorescent (optically silent) in their native (quenched) state, they generate high levels of fluorescence through enzyme-mediated release of their fluorochrome.

  • Map the in vivo status of a disease.
    • Follow progression and responses to potential therapeutics
  • Investigate specific enzyme activity profiles in real time
  • Elucidate protease panels and disease
    • Use with other imaging agents for complementary molecular reporting
  • Highly sensitive
    • A single enzyme cleaving multiple fluorescence agents results in unprecedented signal to background ratios to achieve several hundred-fold signal amplification
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产品名/货号/品牌 简介 包装  
ProSense 680 Sample Size 1UNIT

价格:¥

货号:NEV10724
品牌:PERKINELMER

经销:基因有限公司

ProSense 680近红外荧光探针,检测组织蛋白酶B,L,S及plasmin(胞浆素)

ProSense 750 EX Sample Size 1UNIT

价格:¥

货号:NEV10972EX
品牌:PERKINELMER

经销:基因有限公司

ProSense 750EX近红外荧光探针,检测组织蛋白酶B,L,S及plasmin(胞浆素)

ProSense 750 FAST Sample Size 1UNIT

价格:¥

货号:NEV11172
品牌:PERKINELMER

经销:基因有限公司

ProSense 750FAST近红外荧光探针,检测组织蛋白酶B,L,S及plasmin(胞浆素)。A protease-activatable, pan-cathepsin fluorescent in vivo imaging agent that is activated by key disease associated proteases such as Cathepsin B, L, S, K, V and D. ProSense 750 FAST is not cleaved by trypsin or plasmin.
Cathepsins are produced by inflammatory and tumor cells. ProSense 750 FAST is optically silent in its un-activated state and becomes highly fluorescent following protease-mediated activation. ProSense 750 FAST has a half-life in plasma of 30 minutes. ProSense 750 FAST may be used to study disease onset and progression in animal models of oncology, inflammation and atherosclerosis.

ProSense 680 Bulk 1UNIT

价格:¥

货号:NEV10003B
品牌:PERKINELMER

经销:基因有限公司

ProSense 680近红外荧光探针,检测组织蛋白酶B,L,S及plasmin(胞浆素)

ProSense 750 FAST Bulk 1UNIT

价格:¥

货号:NEV11171B
品牌:PERKINELMER

经销:基因有限公司

ProSense 680 Fluorescent Imaging Agent/ProSense 680近红外荧光探针成像试剂 10 Doses

价格:¥

货号:NEV10003
品牌:PERKINELMER

经销:基因有限公司

ProSense 680近红外荧光探针,检测组织蛋白酶B,L,S及plasmin(胞浆素),可注射10只小鼠。A protease activatable fluorescent in vivo imaging agent that is activated by key disease associated proteases such as Cathepsin B, L, S and Plasmin. ProSense 680 is optically silent in its unactivated state and becomes highly fluorescent following protease-mediated activation. 1 Vial, 10 doses (based on a 20-25 g mouse)
ProSense 680 can be used as a marker for disease progression and therapeutic response in animal models of arthritis. This agent can also be used as a marker for disease progression in animal tumor models.

ProSense 750 EX Fluorescent Imaging Agent/ProSense 750EX近红外荧光探针成像试剂 10 Doses

价格:¥

货号:NEV10001EX
品牌:PERKINELMER

经销:基因有限公司

ProSense 750EX近红外荧光探针,检测组织蛋白酶B,L,S及plasmin(胞浆素),可注射10只小鼠。A protease activatable fluorescent in vivo imaging agent that is activated by key disease associated proteases such as Cathepsin B, L, S and Plasmin. ProSense750 EX is optically silent in its unactivated state and becomes highly fluorescent following protease-mediated activation. 1 Vial, 10 doses (based on a 20-25 g mouse)
ProSense750 EX can be used as a marker for disease progression and therapeutic response in animal models of arthritis. This agent can also be used as a marker for disease progression in animal tumor models.

Neutrophil Elastase 680 FAST Fluorescent Imaging Agent/Neutrophil Elastase 680 FAST近红外荧光探针成像试剂 10 Doses

价格:¥

货号:NEV11169
品牌:PERKINELMER

经销:基因有限公司

Neutrophil Elastase 680 FAST近红外荧光探针用于检测嗜中性粒细胞胰肽酶活性,可注射10只小鼠。A neutrophil elastase activatable agent that is optically silent upon injection and produces fluorescent signal after cleavage by elastase produced by neutrophil cells. Neutrophil elastase is a key protease involved in acute lung injury, acute respiratory distress syndrome, as well as many other inflammatory processes such as emphysema, cystic fibrosis, COPD, wound healing, rheumatoid arthritis, ischemia-reperfusion and many others. 1 Vial, 10 doses (based on a 20-25 g mouse)
Neutrophil Elastase 680 FAST fluorescent imaging agent is a selective neutrophil elastase-activatable agent designed for imaging of this serine protease both in vitro and in vivo. The half-life in plasma of Neutrophil Elastase 680 FAST is 4 hours.

ProSense 750 FAST Fluorescent Imaging Agent/ProSense 750FAST近红外荧光探针成像试剂 10 Doses

价格:¥

货号:NEV11171
品牌:PERKINELMER

经销:基因有限公司

ProSense 750FAST近红外荧光探针,检测组织蛋白酶B,L,S及plasmin(胞浆素),可注射10只小鼠。A protease-activatable, pan-cathepsin fluorescent in vivo imaging agent that is activated by key disease associated proteases such as Cathepsin B, L, S, K, V and D. ProSense 750 FAST is not cleaved by trypsin or plasmin. 1 Vial, 10 doses (based on a 20-25 g mouse)
Cathepsins are produced by inflammatory and tumor cells. ProSense 750 FAST is optically silent in its un-activated state and becomes highly fluorescent following protease-mediated activation. ProSense 750 FAST has a half-life in plasma of 30 minutes. ProSense 750 FAST may be used to study disease onset and progression in animal models of oncology, inflammation and atherosclerosis.

Cat B 680 FAST Fluorescent Imaging Agent/Cat B 680 FAST 近红外荧光探针成像试剂 10 Doses

价格:¥

货号:NEV11112
品牌:PERKINELMER

经销:基因有限公司

Cat B 680 FAST Fluorescent Imaging Agent Cat B 680FAST近红外荧光探针,检测组织蛋白酶B的活性,可注射10只小鼠(20-25g小鼠)。 Cathepsin B activatable fluorescent imaging agent that is optically silent upon injection and produces fluorescent signal after cleavage by Cathepsin B produced by inflammatory cells and tumor cells.1 Vial, 10 doses (based on a 20-25 g mouse)
Cat B 680 FAST may be used to monitor inflammation, tumor activity, progression of disease and the efficacy of therapeutic treatment in applications such as oncology, inflammation, cardiovascular disease and some neurological. This architecture also offers higher target specific signal with reduced background.

Cat B 750 FAST Fluorescent Imaging Agent/Cat B 750 FAST 近红外荧光探针成像试剂 10 Doses

价格:¥

货号:NEV11098
品牌:PERKINELMER

经销:基因有限公司

Cat B 750FAST近红外荧光探针,检测组织蛋白酶B的活性,可注射10只小鼠(20-25g小鼠)。A Cathepsin B activatable fluorescent agent that is optically silent upon injection and produces fluorescent signal after cleavage by Cathepsin B produced by inflammatory cells and tumor cells. Cat B 750 FAST may be used to monitor inflammation, tumor activity, progression of disease and the efficacy of therapeutic treatment in applications such as oncology, inflammation, cardiovascular disease and some neurological diseases. 1 Vial, 10 dose (Based on 20 - 25g mouse). Each vial contains 48 nmol of Cat B 750 FAST in dry solid form.

MMPSense 645 FAST Fluorescent Imaging Agent/MMPSense 645FAST近红外荧光探针成像试剂 10 Doses

价格:¥

货号:NEV10100
品牌:PERKINELMER

经销:基因有限公司

MMPSense 645FAST近红外荧光探针,检测金属蛋白酶活性,包括MMP2、3、7、8、12、13,可注射10只小鼠。 A matrix metalloproteinase (MMP) activatable agent that is optically silent upon injection and produces fluorescent signal after cleavage by disease related MMP’s. Activation can occur by a broad range of MMP’s including MMP 2, 3, 7, 9, 12, and 13.
MMP activity is involved in many disease-related processes including cancer progression, invasion and metastasis, rheumatoid arthritis, pulmonary diseases and areas of cardiovascular disease. MMPSense 645 FAST fluorescent imaging agent may be used to monitor the progression of these diseases or to evaluate the potential therapeutic efficacy of drugs targeting the underlying mechanisms involved in these diseases.

MMPSense 680 Fluorescent Imaging Agent/MMPSense 680近红外荧光探针成像试剂 10 Doses

价格:¥

货号:NEV10126
品牌:PERKINELMER

经销:基因有限公司

MMPSense 680近红外荧光探针,检测金属蛋白酶活性,包括MMP2、3、7、8、12、13,可注射10只小鼠。 A protease activatable fluorescent in vivo imaging agent that is activated by key matrix metalloproteinases (MMPs) including MMP-2, -3, -9 and -13. MMPSense 680 is optically silent in its unactivated state and becomes highly fluorescent following protease-mediated activation. MMP activity is involved in many disease-related processes including cancer progression, invasion and metastasis, rheumatoid arthritis, pulmonary diseases and areas of cardiovascular disease. MMPSense 680 may be used to monitor the progression of these diseases or to evaluate the potential therapeutic efficacy of drugs targeting the underlying mechanisms involved in these diseases.

MMPSense 750 FAST Fluorescent Imaging Agent/MMPSense 750FAST近红外荧光探针成像试剂 10 Doses

价格:¥

货号:NEV10168
品牌:PERKINELMER

经销:基因有限公司

MMPSense 750FAST近红外荧光探针,检测金属蛋白酶活性,包括MMP2、3、7、8、12、13,可注射10只小鼠。 A matrix metalloproteinase (MMP) activatable agent that is optically silent upon injection and produces fluorescent signal after cleavage by disease related MMP’s. Activation can occur by a broad range of MMP’s including MMP 2, 3, 7, 9, 12, and 13. 1 Vial, 10 doses (based on a 20-25 g mouse)
MMP activity is involved in many disease-related processes including cancer progression, invasion and metastasis, rheumatoid arthritis, pulmonary diseases and areas of cardiovascular disease. MMPSense 750 FAST may be used to monitor the progression of these diseases or to evaluate the potential therapeutic efficacy of drugs targeting the underlying mechanisms involved in these diseases.

PSA750 FAST Fluorescent Imaging Agent/PSA750 FAST近红外荧光探针成像试剂 10 Doses

价格:¥

货号:NEV11125
品牌:PERKINELMER

经销:基因有限公司

PSA750 FAST近红外荧光探针,检测前列腺癌的标识物前列腺特异性抗原PSA的酶活性,可注射10只小鼠。24 NMOL. A unique type of activatable in vivo fluorescent reagent that detects and quantifies PSA enzymatic activity at sites of prostate tumor growth. Detect and quantify active PSA non-invasively in vivo. Selective against unbound and complexed PSA High Specificity for PSA+ tumors. Validated on PerkinElmer’s comprehensive line of in vivo imaging systems. 1 Vial, 10 doses (based on a 20-25 g mouse)
Prostate Specific Antigen (PSA) is one of the most studied biomarkers for prostate cancer. However, serum PSA levels are mildly elevated in both malignant and non-malignant prostate conditions. Enzymatically active PSA, present at detectable levels only in prostate tumor tissue, provides a better target to measure the malignancy of prostate cancer.

ReninSense 680 FAST Fluorescent Imaging Agent/ReninSense 680 FAST近红外荧光探针成像试剂 10 Doses

价格:¥

货号:NEV11079
品牌:PERKINELMER

经销:基因有限公司

ReninSense 680 FAST近红外荧光探针检测肾素-血管紧张素通路中肾素表达情况,可注射10只小鼠。A Renin activatable agent that is optically silent upon injection and produces fluorescent signal after cleavage by renin produced in the kidneys. The Renin-Angiotensin System (RAS) is the hormone system involved in regulating blood pressure and fluid balance in the body. 1 Vial, 10 doses (based on a 20-25 g mouse)
ReninSense 680 FAST is recognized and activated by rodent forms of renin in preclinical animal models. ReninSense 680 FAST may be used to monitor abnormal RAS function, progression of disease and the efficacy of therapeutic treatment in disorders such as hypertension and cardiovascular disease and some neurological diseases.

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