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PKC zeta Pseudo-substrate inhibitor, Myristoylated:PKC ζ Pseudo-substrate inhibitor, Myristoylated, 1mg 1Unit

价格:¥

货号:sc-397537
品牌:Santa Cruz

经销:基因生物技术国际贸易(上海)有限公司

A cell-permeable form of the PKCζ isozyme pseudosubstrate inhibitory peptide

NVP-BEZ235:NVP-BEZ235 5mg

价格:¥

货号:13101S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

PX-866:PX-866 1mg

价格:¥

货号:13055S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

SB216763:SB216763 5mg

价格:¥

货号:13621s
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

马来酰亚胺衍生物SB216763是有效的选择性糖原合成酶激酶3(GSK-3)细胞渗透抑制剂。The maleimide derivative SB216763 is a potent and selective cell permeable inhibitor of glycogen synthase kinase 3 (GSK-3). Research studies using peptide-based protein kinase assays show that SB216763 inhibits GSK-3α in an ATP competitive manner with an IC50 of 34 nM, and is an equally effective GSK3-β inhibitor. Molecular Weight:371.20 g/mol;Purity:>98%;Molecular Formula:C19H12Cl2N2O2

Torin 1:Torin 1 5mg

价格:¥

货号:14379s
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

>98% 5 mg 607.64 g/mol C35H28F3N5O2. Torin 1 is a potent and selective ATP-competitive mTOR inhibitor (1,2). Researchers have shown that Torin 1 inhibits mTORC1 and mTORC2 in cell-free kinase assays with IC50 values of 2 nM and 10 nM, respectively (1,2). Torin 1 displays nearly 1000-fold selectivity for mTOR over PI3 Kinase (IC50 ~1.8 μM), 200-fold selectivity over ATM, DNA-PK, and hVps34, and does not significantly inhibit a panel of 353 serine/threonine, tyrosine, and lipid kinases at 10 μM. Torin 1 has also been shown to cause cell cycle arrest via a rapamycin-resistant mechanism independent of mTORC2 (1). Torin 1 treatment of cells leads to the dephosphorylation of mTOR downstream targets including p70 S6 kinase, S6 Ribosomal Protein, and 4E-BP1 (1-4). Activation and nuclear translocation of TFEB (EC50 = ~148 nM) by Torin 1 inhibition of mTORC1 has also been observedTorin 1 is supplied as a lyophilized powder. For a 1 mM stock, reconstitute the 5 mg in 8.23 ml DMSO. First add 1 ml DMSO to the tube containing the chemical, vortex, and dispense into a new, larger tube. Repeat this action two or three more times to transfer any residual material. Add additional DMSO to the new tube to bring the volume up to 8.23 ml. Heating to 37ºC and/or additional vortexing may be required. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 10-1,000 nM for 1-24 hr.

K252a:K252a 100µg

价格:¥

货号:12754S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

100 µg. >99%. K252a is a staurosporine analog that inhibits various protein kinases through competition with the ATP binding site (1,2). K252a is a reversible cell-permeable, potent inhibitor of phosphorylase kinase (IC50 = 1.7 nM), protein kinase A (PKA) (IC50 = 140 nM), and protein kinase C (PKC) (IC50 = 470 nM) (3,4). K252a is also known to inhibit protein kinase G and CaM kinase II (5,6). K252a inhibits nerve growth factor induced Trk activation (IC50 = 3 nM), as well as downstream signaling (5,7,8). K252a is reported to induce apoptosis and cell cycle arrest through cdc25 and cdc2 inhibition. K252a is supplied as a lyophilized powder. For a 1 mM stock, reconstitute the 100 μg in 213.9 µl DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used as a pretreatment at 0.1-1 µM for 0.5-1 hr prior to treating with a stimulator. Soluble in DMSO at 100 mg/ml; poorly soluble in ethanol. C27H21N3O5. MW=467.47 g/mol

Epothilone B:Epothilone B 100µg

价格:¥

货号:12986S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

>99% 100 µg. 507.68 g/mol. C27H41NO6S. Epothilone A and B are taxol-like macrolides originally identified as antifungal, cytotoxic metabolites derived from the myxobacterium Sorangium cellulosum. Research studies demonstrate that epothilone B polymerizes tubulin into microtubules in vitro, which induces mitotic arrest at the G2/M phase and results in inhibition of cell proliferation and cytotoxicity (1-3). Cell cycle arrest at nanomolar IC50 values have been observed in many cell types, including HeLa (IC50 = 32 nM), Hs578T (IC50 = 3 nM) (3), as well as the multiple myeloma cell lines U266 and RPMI 8226 (IC50 = ~1-10 nM) (4). Investigations have shown that both epothilone A and B competitively inhibit binding of taxol to microtubules in vitro . Epothilone B is supplied as a lyophilized powder. For a 1 mM stock, reconstitute the 100 µg in 197 µl DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 10-1000 nM for 12-48 hr.

Axitinib:Axitinib 5mg

价格:¥

货号:12961S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

>99% 5 mg. C22H18N4OS. 386.47 g/mol. Axitinib is a selective inhibitor of VEGFR, PDGFR, and c-kit tyrosine kinases. Researchers performing cellular phosphorylation assays have shown that axitinib very potently inhibits VEGF-1, -2, and -3 with IC50 values of approximately 1.2 nM, 0.2 nM, and 0.1-0.3 nM, respectively. It also effectively inhibits PDGF-α (IC50 = 5.0 nM), PDGF-β (IC50 = 1.6 nM), and c-kit (IC50 = 1.7 nM) (1). Axitinib exhibits little activity against a variety of off-target protein kinases when used at 1 µM (1). It inhibits VEGF-induced endothelial cell proliferation, survival, and tube formation, as well as phosphorylation of downstream targets Akt, eNOS, and ERK1/2 in a dose-dependent manner (1). Research studies demonstrate that axitinib suppresses T cell proliferation in a dose dependent manner through G2/M mitotic arrest, while apoptosis is largely prevented though stabilization of Mcl-1 and inactivation of caspase-9 (2). Axitinib has been shown to reduce both hypoxic-induced tissue permeability and overexpression/secretion of VEGF and PDGF in HUVE and RPE cells, as well as alter junction protein expression. Axitinib is supplied as a lyophilized powder. For a 10 mM stock, reconstitute the 5 mg in 1.29 ml DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used as a pretreatment at 1-1000 nM for 0.5-2 hr prior to treating with a stimulator. It can also be used alone, with varying treatment times lasting up to 72 hr.

Vorinostat (SAHA):Vorinostat (SAHA) 5mg

价格:¥

货号:12520S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

5 mg. MW=264.32 g/mol. C14H20N2O3. >99%. Vorinostat (SAHA) is a histone deacetylase (HDAC) inhibitor that acts by binding to and blocking the active site of the enzyme (1). Both class I and class II HDACs are inhibited by vorinostat at nanomolar concentrations (1-3). Research studies have shown that vorinostat causes the accumulation of acetylated histones, certain transcription factors, and other nonhistone proteins, which regulate gene expression and protein function. This leads to cell cycle arrest, differentiation, and/or apoptosis in many transformed cell types treated with micromolar concentrations of vorinostat. Vorinostat is supplied as a lyophilized powder. For a 20 mM stock, reconstitute the 5 mg in 945.8 µl DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 1-10 µM for 2-24 hr. Soluble in DMSO at 66 mg/ml; soluble in ethanol at 2 mg/ml with slight warming; very poorly soluble in water with maximum solubility ~20-50 µM.

Pazopanib:Pazopanib 10mg

价格:¥

货号:12466S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

10 mg. >99%. MW=437.52 g/mol. C21H23N7O2S. Pazopanib is a multikinase inhibitor that potently targets VEGFR1 (IC50 = 10 nM), VEGFR2 (IC50 = 30 nM), VEGFR3 (IC50 = 47 nM), PDGFRα (IC50 = 71 nM), PDGFRβ (IC50 = 84 nM), and c-Kit (IC50 = 74 nM) tyrosine kinases involved in tumor progression and angiogenesis, and can also inhibit many other tyrosine kinases at nanomolar concentrations. Research studies have demonstrated that pazopanib effectively blocks ligand-induced autophosphorylation of VEGFR2, PDGFRβ, and c-Kit in vitro, and selectively inhibits VEGF-induced HUVE cell proliferation over FGF (IC50 = ~21 nM vs ~720 nM). Investigators have demonstrated that pazopanib inhibits the growth, survival, and migration of multiple myeloma (MM) cell types. Soluble in DMSO at 8 mg/mL with slight warming; very poorly soluble in ethanol and water with maximum in water ~10-20 µM. Pazopanib is supplied as a lyophilized powder. For a 10 mM stock, reconstitute the 10 mg in 2.29 ml DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used as a pretreatment at 0.1-10 µM for 0.5-2 hr prior to treating with a stimulator. It can also be used alone, with varying treatment times lasting up to 24 hr.

Vandetanib :Vandetanib  5mg

价格:¥

货号:12616S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

5 mg. MW=475.35 g/mol. C22H24BrFN4O2. >99%. Vandetanib, also known as ZD6474, is a selective inhibitor of VEGFR and EGFR tyrosine kinases (1-5). Researchers have shown that vandetanib inhibits VEGFR-2, VEGFR-3, and EGFR in recombinant enzyme assays with IC50 values of 40 nM, 108 nM, and 500 nM, respectively, and had selectivity over a variety of other tyrosine and serine/threonine kinases (2). Vandetanib inhibits VEGF and EGF stimulated proliferation of HUVE cells with an IC50 of 60 nM and 170 nM, respectively (2), and effectively blocks VEGF and EGF induced autophosphorylation (3-5). Inhibition of RET by vandetanib has also been observed. Vandetanib is supplied as a lyophilized powder. For a 10 mM stock, reconstitute the 5 mg in 1.05 ml DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used as a pretreatment at 1-10 µM for 0.5-2 hr prior to treating with a stimulator. It can also be used alone, with varying treatment times lasting up to 24 hr. Soluble in DMSO at 30 mg/ml; soluble in ethanol at 10 mg/ml with warming; very poorly soluble in water with maximum ~10-20 µM.

Vincristine:Vincristine 5mg

价格:¥

货号:13043S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

>99% 5 mg. 923.04 g/mol. C46H56N4O10•H2SO4. Vincristine is a vinca alkaloid isolated from the plant Catharanthus roseus that acts as a mitotic inhibitor blocking microtubule assembly in vitro (1,2). Research studies demonstrated that vincristine binds to and inhibits the addition of tubulin dimers to the assembly end of steady-state microtubules in a dose-dependent manner (Ki = ~85 nM) (1). Additional research suggests that high concentrations of vincristine depolymerize microtubules (2). Disruption of mitotic spindle function has been shown to cause mitotic arrest, inhibit cell proliferation, and induce apoptosis in numerous cell types. Vincristine is supplied as a lyophilized powder. For a 10 mM stock, reconstitute the 5 mg in 541.7 µl DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 10-1000 nM for 12-48 hr.

Lipopolysaccharides (LPS):Lipopolysaccharides (LPS) 10mg

价格:¥

货号:14011S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

10 mg. Lipopolysaccharide (LPS), also known as endotoxin, is a major glycolipid constituent of the outer cell wall of gram-negative bacteria. LPS molecules typically consist of a strain-specific distal polysaccharide side chain known as the O-antigen, a hydrophilic core oligosaccharide, and a hydrophobic domain referred to as lipid A. Lipid A is covalently bound to the outer bacterial membrane and is responsible for the toxicity of LPS (1-3). LPS is a potent activator of the proinflammatory response in many mammalian cell types, including macrophages, monocytes, and endothelial cells. Investigators have demonstrated that LPS binds to the CD14/TLR4/MD2 receptor complex, which in turn induces inflammatory cytokines including TNF-α, Interleukin-1, and IFN-α, as well as numerous inflammatory proteins such as iNOS, NF-κB, RIG-1, and IRF-3 For a 1 mg/ml stock, reconstitute the 10 mg in 10 ml sterile PBS. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 10-1000 µg/ml for 15 min-24 hours. Soluble in PBS and cell culture medium at 5 mg/ml and 1 mg/ml, respectively.

Phosphatase Inhibitor Cocktail A:Phosphatase Inhibitor Cocktail A 1 ml

价格:¥

货号:sc-45044
品牌:Santa Cruz

经销:基因生物技术国际贸易(上海)有限公司

An inhibitor of L-isozymes of alkaline phosphatase and ser/thr protein phosphatases

Thapsigargin:Thapsigargin 1mg

价格:¥

货号:12758S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

毒胡萝卜素,促肿瘤生长因子,亦可抑制内质网中Ca2+-ATPases活性,进而促进细胞质中钙离子浓度的快速增加,参与ER应急反应。 Thapsigargin

Tunicamycin:Tunicamycin 5mg

价格:¥

货号:12819S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

衣霉素,抑制糖蛋白合成过程中N-连接糖基化 Tunicamycin,5mg

Vatalanib:Vatalanib 5mg

价格:¥

货号:12998S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

瓦他拉尼,5mg,多靶酪氨酸酶抑制剂 Vatalanib,5mg

SB203580:SB203580 5mg

价格:¥

货号:5633S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

p38 MAPK的选择性抑制剂,5mg SB203580, 5mg

Nilotinib:Nilotinib 5mg

价格:¥

货号:12209S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

尼洛替尼,酪氨酸酶抑制剂,抑制 Bcr-Ab,l5mg。 Nilotinib, 5mg

PD184352:PD184352 5mg

价格:¥

货号:12147S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

MEK抑制剂,阻断MAPK激活,影响细胞增殖过程。5mg。 PD184352, 5mg

Everolimus:Everolimus 1mg

价格:¥

货号:12017S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

依维莫司,亦称作RAD001,与FKBP12结合形成复合体,结合并抑制mTORC1活性。 Everolimus, 1mg

Lapatinib:Lapatinib 10mg

价格:¥

货号:12121S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

拉帕替尼,EGFR和HER2酪氨酸激酶抑制剂,10mg Lapatinib, 10mg

Gö6976:Gö6976 500µg

价格:¥

货号:12060S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

ATP依赖型的蛋白酶C和蛋白酶D抑制剂,500ug。 Gö6976, 500ug

MG-132:MG-132 1mg

价格:¥

货号:2194S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

反应种属:Human

蛋白酶体和钙蛋白酶抑制剂 MG-132, 1mg

Chelerythrine Chloride:Chelerythrine Chloride 5mg

价格:¥

货号:11916S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

白屈菜赤碱,蛋白酶C抑制剂,5mg Chelerythrine Chloride, 5mg

Cycloheximide:Cycloheximide 1g

价格:¥

货号:2112S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

环己酰亚胺,蛋白合成抑制剂,1g Cycloheximide, 1g

Sunitinib:Sunitinib 10mg

价格:¥

货号:12328S
品牌:CST

经销:基因生物技术国际贸易(上海)有限公司

舒尼替尼,多功能酪氨酸激酶抑制剂,10mg Sunitinib, 10mg

Phosphatase Inhibitor Cocktail C:Phosphatase Inhibitor Cocktail C 1 ml

价格:¥

货号:sc-45065
品牌:Santa Cruz

经销:基因生物技术国际贸易(上海)有限公司

An inhibitor of alkaline and ser/thr phosphatases used for research purposes

Phosphatase Inhibitor Cocktail B:Phosphatase Inhibitor Cocktail B 1 vial

价格:¥

货号:sc-45045
品牌:Santa Cruz

经销:基因生物技术国际贸易(上海)有限公司

An inhibitor of PTP-ases as well as acid and alkaline phosphatases

氟化钠(氟化物):Sodium Fluoride (Fluoride) 1 ml

价格:¥

货号:P0759S
品牌:NEB

经销:基因生物技术国际贸易(上海)有限公司

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